He graduates in Architecture in 1968, collaborates with Renzo Piano in Genoa and Paris. In 1992 founds in Paris the Mario Cucinella Architects (MCA) studio and in 1999 opens a new base in Bologna.  Currently he is professor at the Faculty of Architecture Federico II di Napoli, he is Honorary Professor at the University of Nottingham in the UK and Guest Professor in Emerging Technologies at the Technische Universitat at Munich. He is an international point of reference regarding sustainable design. In 2012 he founds Building Green Futures, a no-profit organization which aim is to join environmental culture and technology in order to create an architecture able to guarantee dignity, quality and performance respecting the environment. He can boast numerous and valuable awards, one of the most recent ones is the RIBA International Fellowship 2016 award. His best works are Sino Italian Ecological Building (SIEEB) in Beijing, the Kuwait School in Gaza, the building One Airport Square in Accra in Ghana, the San Raffaele Hospital in Milan.